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Image Search Results
Journal: PLoS ONE
Article Title: Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model
doi: 10.1371/journal.pone.0101764
Figure Lengend Snippet: A, B) Influx of CD4 + and CD8 + tumor infiltrating lymphocytes respectively was higher in brains of animals treated with immunotherapy with 4-1BB activation and CTLA-4 blockade and triple therapy compared to brains from non-tumor bearing mice ( p <0.05). C, D) Cervical lymph nodes from naïve mice showed a higher baseline of CD4 + and CD8 + T cells which resulted in comparable densities of T cells between all groups. Error bars represent standard error of the mean (SEM) and p values were calculated with the student t-test.
Article Snippet: Hamster and rat IgG to serve as control antibodies were purchased from
Techniques: Activation Assay
Journal: PLoS ONE
Article Title: Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model
doi: 10.1371/journal.pone.0101764
Figure Lengend Snippet: Kaplan Meier survival curves for untreated animals, triple therapy (no depletion), triple therapy with depleted CD4 + T cells and triple therapy with depleted CD8 + T cells ( n = 5–7 mice/group). CD4 + T cell depletion abolishes the survival benefit of triple therapy ( p <0.001). Depletion of CD8 + T cells did not interfere with the efficacy of triple therapy and resulted in long-term survival.
Article Snippet: Hamster and rat IgG to serve as control antibodies were purchased from
Techniques: